FoundationOne can potentially match clinically relevant alterations found in lung cancer samples to targeted lung cancer treatments and clinical trials.2,8 This can then assist the physician in tailoring patient management. To date, FoundationOne has generated over xxx non-small cell lung cancer (NSCLC) and secondary lung cancer profiles. These data continue to facilitate the advancement of FoundationCORE, the Foundation Medicine comprehensive genomic database.6 

Clinical relevance of FoundationOne in lung cancer

Over the last decade alone, the number of targetable lung cancer genes has increased.16 In 2015, 96 genomic alterations were identified across 31 patients with lung adenocarcinoma.8 As the fraction of known cancer genes grows, the number of targets for specific therapies increases and it becomes less feasible to test for each individual alteration.5,8,10,11 FoundationOne overcomes this issue by achieving broad coverage of hundreds of known oncogenes in order to maximise the chance of identifying clinically relevant alterations in each patient’s tumour sample.1,5
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FoundationOne could expand treatment options for lung cancer patients

FoundationOne can detect alterations in lung cancers that may be missed by other standard of care measures, including non-NGS fluorescence in situ hybridisation (FISH) testing, potentially expanding treatment options.18 FoundationOne is suitable in the profiling of all solid tumours, including non-small cell lung cancer (NSCLC) and lung adenocarcinomas.8,18

In 2015, 96 genomic alterations were detected across 31 patients with lung adenocarcinoma using FoundationOne’s comprehensive genomic profiling.8

In a study of people with NSCLC, comprehensive genomic profiling identified 35% of ALK gene alterations that were missed by FISH.18

COMPREHENSIVE GENOMIC PROFILING FACILITIES THE IMPLEMENTATION OF THE NCCN GUIDELINES FOR LUNG CANCER BIOMARKER TESTING BY ENABLING SIMULTANEOUS DETECTION OF ALL ALTERATIONS LISTED BY NCCN19
In 71% of patients, FoundationOne detected  ≥1 genomic alteration(s) that occur within the 8 best-
characterised NSCLC driver oncogenes*19. Among these:
of patients were
identified with
potentially actionable
alterations as listed
in the NCCN guidelines**19

*EGFR, ALK, ROS1, RET, met, braf, erbb2, kras

**Alteration definied as actionable if associated with potential benfit from
targeted therapy or enabled enrolment in mechanism-driven clinical trial.

FoundationOne has been shown to expand lung cancer treatment options in a real-world setting, allowing physicians to action the results through normal prescribing routes, special access programmes or clinical studies.2

of lung cancer patients were identified by FoundationOne® as
having at least 1 driver associated with US FDA approved
anticancer therapies for all cancer types (n=73/82).2

of patients were provided
with a change in treatment strategy
(i.e. intiation of appropriate targeted
therapy) (n=36/82).1
of patients received US
FDA-approved targeted
therapy (n=37/82).1
of patients responded to their
change in therapy, with 14%
(5/43) achieveing a complete
response and 50% experiencing
a partial response (17/43)1

In order to identify the most appropriate targeted treatment, there is a need for an accurate diagnostic test that can identify all clinically relevant alterations.5,8

The National Comprehensive Cancer Network guidelines for NSCLC strongly recommend the use of broader molecular profiling for lung cancer, providing an even greater rationale for the use of FoundationOne tumour profiling.20

In addition to the identification of these alterations, FoundationOne has also been used to identify a possible association between TMB and predicted response to immunotherapy, meaning that physicians could potentially use FoundationOne in order to estimate patient response to immunotherapy.2

Is FoundationOne suitable for all cancer types?

FoundationOne is suitable for all solid cancer types, including rare cancers and cancers of unknown origin, and in recurrent or metastatic solid tumour cancers, including all lung cancer types.1,7

FoundationOne can be useful in cases where there are many possible treatment options to choose between, limited treatment options or where the solid tumour may have uncommon or rare alterations that would be missed by routine testing.8–10

References
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  6. Foundation Medicine. FoundationCORE press release, June 2016.
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